HSC may refer to

• Higher School Certificate, the final examination in secondary school education in New South Wales, Australia.
• Higher Secondary (School) Certificate, the "certificate" given to students passing out of higher secondary school/junior college in Bangladesh, and also in Maharashtra, India. Also refers to the final examination taken by thousands of students of Grade 12 (Called Standard 12 in India) in Maharashtra
• Hindu students council, is an international forum that provides opportunities to learn about Hindu heritage through various activities, events and projects.
• Hitachi Storage Cluster
• Hematopoietic stem cell, stem cells found in the bone marrow
• Home Shopping Club, the old name of the Home Shopping Network
• Hospital for Sick Children, a pediatric hospital in Toronto, Canada.
• Center for Studying Health System Change, a health policy research organization in Washington, D.C.